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Determination of biomarkers of propylene glycol monomethyl ether in urine by paper spray mass spectrometry
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Meng-meng LIU1, Jun-yu PAN1, Bo-yi LV1, Bao-feng LIU1, Qiang ZENG1, 2
Modern Preventive Medicine | 2025, 52(19) : 3615 - 3619
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Modern Preventive Medicine | 2025, 52(19): 3615-3619
• Experimental Technology and Applications •
Determination of biomarkers of propylene glycol monomethyl ether in urine by paper spray mass spectrometry
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Meng-meng LIU1, Jun-yu PAN1, Bo-yi LV1, Bao-feng LIU1, Qiang ZENG1, 2
Affiliations
  • Department of Occupational Health, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China
Published: 2025-10-10 doi: 10.20043/j.cnki.MPM.202505145
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Objective To establish a paper spray mass spectrometry method for the determination of 1-methoxy-2-propanol and 2-methoxypropionic acid as biomarkers of propylene glycol monomethyl ether in urine. Methods The urine sample was dropped onto the chromatographic paper, and a high voltage of 4 kV was applied to the back of the paper. After dissolution in the spray solvent, the sample formed an electrospray at the paper tip under the effect of voltage, which then entered the mass spectrometer for detection. Results The linear ranges of 1-methoxy-2-propanol and 2-methoxypropionic acid were 0.036-46.15 μg/mL and 0.029-54.25 μg/mL, respectively, with correlation coefficients ranging from 0.999 6 to 0.999 9. The detection limit (LOD) was between 0.008 8 and 0.011 μg/mL, and the quantification limit(LOQ) was between 0.029 and 0.036 μg/mL. The sample recovery rate ranged from 90.8% to 105.0%, and RSDs ranged from 3.3% to 9.7%. Conclusion This method requires no sample processing, features simplicity, rapidity and high sensitivity, making it suitable for the rapid screening of propylene glycol monomethyl ether in urine.

Urine  /  Paper spray mass spectrometry  /  Propylene glycol monomethyl ether  /  Metabolites
Meng-meng LIU, Jun-yu PAN, Bo-yi LV, Bao-feng LIU, Qiang ZENG. Determination of biomarkers of propylene glycol monomethyl ether in urine by paper spray mass spectrometry[J]. Modern Preventive Medicine, 2025 , 52 (19) : 3615 -3619 . DOI: 10.20043/j.cnki.MPM.202505145
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Year 2025 volume 52 Issue 19
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doi: 10.20043/j.cnki.MPM.202505145
  • Receive Date：2025-05-12
  • Online Date：2026-03-17
  • Published：2025-10-10
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  • Received：2025-05-12
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    Department of Occupational Health, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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