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Objective To explore the relationship between low grip strength and the occurrence of falling in the elderly. Methods A cohort study was conducted using the China Healh and Retirement Longiudinal Sudy (CHARLS) database, including individuals without a history of falling at the 2011 baseline. Demographic characteristics, chronic disease history, and grip strength information of the subjects were collected. Subjects were grouped based on whether they experienced falling during the follow-up from 2013 to 2020. Multivariable logistic regression analysis was used to examine the relationship between low grip strength and falling occurrence. The causal relationship between low grip strength and falling was assessed using two-sample MR based on the corresponding datasets. Datasets were sourced from the IEUGWAS database. MR analysis was conducted using inverse variance weighting (IVW), MR-Egger regression, weighted median estimation (WME), simple mode,and weighted mode methods. Cochran’s Q test, MR-pleiotropy, and leave-one-out methods were employed to evaluate pleiotropy, sensitivity, and heterogeneity. Results After adjusting for age, gender, marital status, disease status and other related confounding factors, low grip strength was still associated with the occurrence of falling. Compared with the normal grip group, the low grip group had an increased risk of falling (OR=1.29, 95% CI: 1.06-1.56, P=0.01). The results of MR also showed that low grip strength increased the occurrence of falling. Conclusion Low grip strength is associated with falling in the elderly. The elderly with low grip strength have a higher risk of falling.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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