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Relationship between body roundness index and depression risk among individuals with hyperlipidemia
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Jian LI1, Gang WANG2, Qiu-jing LI3, Li-chun ZHOU1
Modern Preventive Medicine | 2025, 52(19) : 3509 - 3514
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Modern Preventive Medicine | 2025, 52(19): 3509-3514
• Epidemiology and Statistical Methods •
Relationship between body roundness index and depression risk among individuals with hyperlipidemia
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Jian LI1, Gang WANG2, Qiu-jing LI3, Li-chun ZHOU1
Affiliations
  • Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China
Published: 2025-10-10 doi: 10.20043/j.cnki.MPM.202504437
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Objective To examine the relationship between body roundness index (BRI) and depression risk in individuals with hyperlipidemia. Methods Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2005—2018, including 20 492 adults with hyperlipidemia. Multivariable logistic regression and restricted cubic spline analyses were used to analyze the association between BRI and depressive status. Results Multivariable analysis revealed a significant U-shaped relationship between BRI and depression risk (P=0.002), with an inflection point at 3.15. For BRI<3.15, each unit increase in BRI was associated with a 33% decrease in depression risk (OR=0.67, 95% CI: 0.50-0.88, P=0.004 3). For BRI≥3.15, each unit increase in BRI was associated with a 7% increase in depression risk (OR=1.07, 95% CI: 1.04-1.09, P<0.000 1). In tertile analysis, the highest BRI tertile showed a 30% increased risk of depression compared to the lowest tertile(OR=1.30, 95% CI: 1.13-1.49, P=0.000 2). Conclusion There is a U-shaped relationship between BRI and depression risk in individuals with hyperlipidemia, suggesting that both excessively low and high BRI values may increase the risk of depression.Large prospective cohort studies are needed to validate these findings.

Body roundness index  /  Depression  /  Hyperlipidemia  /  Cross-sectional study  /  NHANES
Jian LI, Gang WANG, Qiu-jing LI, Li-chun ZHOU. Relationship between body roundness index and depression risk among individuals with hyperlipidemia[J]. Modern Preventive Medicine, 2025 , 52 (19) : 3509 -3514 . DOI: 10.20043/j.cnki.MPM.202504437
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Year 2025 volume 52 Issue 19
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doi: 10.20043/j.cnki.MPM.202504437
  • Receive Date：2025-04-25
  • Online Date：2026-03-17
  • Published：2025-10-10
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  • Received：2025-04-25
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    Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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