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To investigate the differences in gut flora between infants and children aged 0~3 years with atopic dermatitis (AD) and healthy infants and children.
General information and fecal samples were collected from children with AD aged 0-3 years (AD group) and healthy infants and children (HC group). T Test and Chi-Square Tests were used to analyze the general information of infants and children in two groups, and 16S rRNA sequencing technology combined with bioinformatics analysis to compare the diversity and differences of intestinal flora in two groups.
General information only history of allergy in the immediate family was significantly different between the two groups (χ2=13.875, P<0.001). The difference in the diversity of Gut microbiota between the two groups was not statistically significant. At the gate level, the relative abundance of Verrucomicrobiota was significantly lower in the AD group than in the HC group (P=0.027), whereas the relative abundance of Fusobacteriota was significantly higher than in the HC group (P=0.038). At the genus level, the relative abundance of the genera Cetobacterium (P=0.010), Dysgonomonas (P=0.013), and Fusicatenibacter (P=0.044) in the AD group was significantly higher than that in the HC group, while the relative abundance of the genera Actinomyces (P=0.029), Collinsella (P=0.017) and Eggerthella (P=0.028) were significantly lower in relative abundance than the HC group. LEfSe analysis showed that the relative abundance of Coriobacteriaceae (P=0.017) and Bifidobacterium_longum (P=0.002) in the AD group was significantly lower than that in the HC group.
There are some differences in the composition of the Gut microbiota between the AD and HC groups. Differential microorganisms such as Fusicatenibacter, Eggerthella, Actinomyces and Bifidobacterium_longum may have a correlation with AD development, suggesting that regulating the Gut microbiota early in life may prevent and treat AD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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