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Causal relationship between lipids and non-alcoholic fatty liver disease: a two-sample Mendelian randomization study
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Peng-yue SHEN, Wen-qiang ZHANG, De-qin HUANG, Lin HE, Xia JIANG, Ben ZHANG
Modern Preventive Medicine | 2024, 51(12) : 2146 - 2151
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Modern Preventive Medicine | 2024, 51(12): 2146-2151
• Epidemiology and Statistical Methods Advances •
Causal relationship between lipids and non-alcoholic fatty liver disease: a two-sample Mendelian randomization study
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Peng-yue SHEN, Wen-qiang ZHANG, De-qin HUANG, Lin HE, Xia JIANG, Ben ZHANG
Affiliations
  • West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Published: 2024-06-25 doi: 10.20043/j.cnki.MPM.202309532
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Objective

To evaluate the causal relationships between lipids (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol [HDL-C], triglyceride [TG], apolipoprotein A-I [ApoA-I], apolipoprotein B) and non-alcoholic fatty liver disease (NAFLD) through a two-sample Mendelian randomization (MR) study.

Methods

Summary datasets of genome-wide association studies of lipids and NAFLD in European ancestry were leveraged, and single nucleotide polymorphisms associated with lipids were selected as instrumental variables. Several univariable MR analyses were conducted, including inverse-variance weighting method, MR-Egger regression, weighted median estimation, MR pleiotropy residual sum and outlier method. A multivariable inverse-variance weighting method was further used to evaluate the independent causal effect of lipids on NAFLD.

Results

Univariable inverse-variance weighting MR showed that genetically predicted higher HDL-C (OR=0.774, 95%CI: 0.708-0.845, P<0.001) and ApoA-I (OR=0.878, 95%CI: 0.796-0.968, P=0.009) were associated with a lower risk of NAFLD, while genetically predicted higher TG (OR=1.323, 95%CI: 1.201-1.458, P<0.001) was associated with a higher risk of NAFLD. The causal effects of HDL-C and TG on NAFLD remained consistent in multivariable MR when adjusting for other lipids, body mass index, and type-2 diabetes.

Conclusion

Our study supports a putative causal relationship between HDL-C, TG, and NAFLD.

Mendelian randomization  /  Lipids  /  Non-alcoholic fatty liver disease  /  Causal inference
Peng-yue SHEN, Wen-qiang ZHANG, De-qin HUANG, Lin HE, Xia JIANG, Ben ZHANG. Causal relationship between lipids and non-alcoholic fatty liver disease: a two-sample Mendelian randomization study[J]. Modern Preventive Medicine, 2024 , 51 (12) : 2146 -2151 . DOI: 10.20043/j.cnki.MPM.202309532
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Year 2024 volume 51 Issue 12
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Article Info
doi: 10.20043/j.cnki.MPM.202309532
  • Receive Date：2023-09-28
  • Online Date：2026-03-17
  • Published：2024-06-25
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  • Received：2023-09-28
Affiliations
    West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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