To understand the prevalence and trend of hepatitis A and E in Yantai from 2011 to 2022, and to conduct serological research on hepatitis A and hepatitis E in the community population so as to provide data for effective prevention and control of two types of hepatitis.

The case-related information came from the monitoring data of China Disease Prevention and Control Information System. Descriptive epidemiological methods were used to analyze the prevalence of hepatitis A and hepatitis E in Yantai City from 2011 to 2022. Two areas in Yantai were selected bymulti-stage random cluster sampling method to carry out monitoring of hepatitis A and hepatitis E antibody levels in community populations. Enzyme linked immunosorbent assay (ELISA) was used to detect serum levels of anti-hepatitis A virus (HAV) and hepatitis E virus (HEV) antibodies.

A total of 858 cases of hepatitis A and 3 145 cases of hepatitis E were reported from 2011 to 2022. The annual average incidence rate of hepatitis A was 1.01/100 000, and the incidence was sporadic throughout the year.The annual average incidence rate of hepatitis E was 3.72/100 000. The incidence was mainly in winter and spring. The reported cases of hepatitis A and hepatitis E were mainly concentrated in the northern coastal areas. 86.48% of the reported cases of hepatitis A are 25-69 years old, while 91.86% of the reported cases of hepatitis E were 35-79 years old.The composition of hepatitis A and hepatitis E was mainly men and farmers. A total of 600 blood samples were collected from healthy people, the overall seroprevalence of HAV IgM, HEV IgM, HAV IgG and HEV IgG were 1.83%, 85.67% and 32%, respectively. In terms of age, the positive rate of HAV IgM was the highest in 61-70 years old group (3.9%), HAV IgG positive rate in over 70 years old group was the highest, HEV IgM positive rate in 51-60 years old group was the highest (4.21%),and HEV IgG positive rate in over 70 years old group was the highest. Farmers had the highest positive rates of HAV IgG and HEV IgG, while students, household workers, and unemployed individuals have the highest positive rates of HAV IgM and HEV IgM. Farmers had the highest positive rates of HAV IgG (92.52%) and HEV IgG (46.26%), students had the highest positive rates of HAV IgM (2.78%) and housework and unemployed people had the highest positive rates of HAV IgM and HEV IgM (3.17%).

The incidence of hepatitis A and hepatitis E remained at a relatively high level in Yantai from 2011 to 2022, and the positive levels of HAV IgG and HEV IgG antibodies were relatively high. Further efforts need to be made to promote and intervene in key populations, especially men and farmers, to carry out relevant prevention and control measures and reduce infection rates.