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To analyze the molecular characteristics and antimicrobial resistance of human-derived Salmonella strains from three cities in Henan during 2023 and 2024, providing a scientific basis for epidemiological surveillance and disease control.
Whole-genome sequencing was performed to analyze multilocus sequence typing (MLST), molecular serotyping, protein function, resistance genes, and virulence genes. Antimicrobial susceptibility was determined by the broth microdilution method.
A total of 53 human-derived Salmonella strains were collected from sentinel hospitals in Xuchang, Nanyang, and Zhoukou. The analysis revealed 16 ST types and 15 molecular serotypes, with Salmonella Enteritidis ST11 being the most prevalent (33.96%). Thirty-two virulence gene categories were identified, and all strains carried numerous genes associated with Salmonella pathogenicity islands. Fifteen classes of resistance genes were detected, with a multidrug resistance (MDR) rate of 67.92%. Minimum spanning tree clustering identified two clonal groups, and phylogenetic analysis showed a strong correlation between ST types and serotypes.
The 53 human-derived Salmonella strains harbored diverse resistance genes and highly pathogenic virulence genes, with Salmonella Enteritidis ST11 being the dominant strain.The high MDR prevalence warrants attention in disease prevention and control.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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