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To explore the causal relationship between type 2 diabetes mellitus (T2DM) and the risk of lung cancer (LC) (including three subtypes: lung adenocarcinoma (LAC), lung squamous cell carcinoma (LSCC), and small cell lung carcinoma (SCLC)) using a two-sample Mendelian randomization approach (MR).
The analysis was performed using summary datasets of genome-wide association studies (GWAS) conducted in European ancestry. Using 380 genome-wide significant single nucleotide polymorphic loci (SNP) associated with type 2 diabetes mellitus as instrumental variables (IV), the primary analysis used inverse variance weighted (IVW) method, MR-Egger regression and weighted median estimator method to investigate the causal association between type 2 diabetes mellitus and lung cancer and its subtypes. Sensitivity analyses were performed including MR-Egger regression intercept test, removing SNPs associated with potential confounding traits, excluding palindromic SNPs, and “leave one out” method.
IVW method showed that genetically predicted type 2 diabetes mellitus was not associated with the risk of lung cancer and its subtypes (LC OR: 1.003, 95% CI: 0.974-1.034; LAC OR: 0.981, 95% CI: 0.943-1.021; LSCC OR: 1.043, 95% CI: 0.995-1.093; SCLC OR: 0.988, 95% CI: 0.921-1.061, respectively). The results remained consistent by using MR-Egger method and weighted median estimator method. The robustness of results was collaborated by several sensitivity analyses. Conclusions This study dosen’t provide evidence supporting the causal relationship between type 2 diabetes mellitus and the risk of overall lung cancer and its subtypes.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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