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Bidirectional causal relationship between multiple sclerosis and inflammatory bowel disease based on Mendelian randomization
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Wen-zhao GUO1, Ying FAN2, Xiao LI1, Guan-hua LV3
Modern Preventive Medicine | 2024, 51(6) : 970 - 973
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Modern Preventive Medicine | 2024, 51(6): 970-973
• Epidemiology and Statistical Methods Advances •
Bidirectional causal relationship between multiple sclerosis and inflammatory bowel disease based on Mendelian randomization
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Wen-zhao GUO1, Ying FAN2, Xiao LI1, Guan-hua LV3
Affiliations
  • Department of Graduate School, Liaoning University of Chinese Medicine, Shenyang, Liaoning 110847, China
Published: 2024-03-25 doi: 10.20043/j.cnki.MPM.202308193
Outline
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Objective

To explore the bidirectional causal relationship between multiple sclerosis (MS) and inflammatory bowel disease (IBD).

Methods

The dataset was pooled by genome-wide association studies (GWAS), of which MS data contained 14 498 samples and IBD data contained 24 865 samples, including 6 968 cases of ulcerative colitis (UC) and 17 897 cases of Crohn’s disease (CD). Random effect inverse variance weighting (IVW), weighted median (WME), MR-Egger regression, and weighted model were used for MR Analysis.

Results

MS was found to increase the risk of UC (IVW: OR=1.108; 95% CI: 1.012-1.213; P<0.05), but not associated with the risk of CD (IVW: OR=1.021; 95% CI: 0.926-1.127; P>0.05); UC also increased the risk of MS, and the two were causal (IVW: OR=1.096; 95% CI: 1.027-1.169; P<0.05), and CD was associated with an increased risk of MS (IVW: OR=1.133; 95% CI: 1.003-1.279; P<0.05). After the MR-Egger regression intercept item test, it was found that there was no horizontal pleiotropy (P>0.05). The heterogeneity test results were all <0.001, so we should pay more attention to the random effects IVW model.

Conclusion

MS is associated with an increased risk of UC, but the effect on CD is not significant. IBD increases the risk of developing MS.

Multiple sclerosis  /  Inflammatory bowel disease  /  Mendelian randomization
Wen-zhao GUO, Ying FAN, Xiao LI, Guan-hua LV. Bidirectional causal relationship between multiple sclerosis and inflammatory bowel disease based on Mendelian randomization[J]. Modern Preventive Medicine, 2024 , 51 (6) : 970 -973 . DOI: 10.20043/j.cnki.MPM.202308193
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Article Info
doi: 10.20043/j.cnki.MPM.202308193
  • Receive Date：2023-08-11
  • Online Date：2026-03-16
  • Published：2024-03-25
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  • Received：2023-08-11
Funding
Affiliations
    Department of Graduate School, Liaoning University of Chinese Medicine, Shenyang, Liaoning 110847, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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