To systematically assess the trend of high BMI-related gout disease burden in China, Japan and Korea and globally from 1990 to 2021, and to provide a scientific basis for gout prevention and control.

Based on data from the Global Burden of Disease Study (GBD), the disease burden characteristics of high BMI-induced gout were resolved by gender and age group,and trends in the rate of standardized disability-adjusted life years (DALYs) were analyzed by using the Joinpoint regression model,and trends in the burden of disease were predicted for the period of 2022-2035 by the ARIMA model.

From 1990 to 2021,the rates of standardized DALYs among adults in China,Japan,Korea,and the world showed a simultaneous upward trend,with an increase of 114.82% in China,which was significantly higher than that of Japan(38.41%),Korea(62.40%), and the global average(62.01%). Gender analysis showed that the rate of standardized DALYs was higher in males than in females in all regions. The age distribution showed a single-peak pattern of increasing and then decreasing, with peak ages of 55-59 years for males and 65-69 years for females in China and globally, whereas peak ages were reached most recently in Japan for males(70-74 years) and females(75-79 years), and peak ages for males in South Korea(60-64 years) were in the middle of the range between China and Japan, and peak ages for females were in line with the global trend(65-69 years).The results of the Joinpoint regression showed that the peak ages of 1990-2021 DALYs rates of gouty diseases attributable to high BMI in China,Japan,and Korea and globally were on the rise in 2021 (AAPC was 2.50%,1.04%,1.58%,and 1.58%,respectively,all P<0.05).

The burden of gout associated with high BMI continues to increase in China,Japan,Korea,and globally,and it is necessary to strengthen the comprehensive management of BMI in the population and to implement focused interventions for high-risk age and gender groups.