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To investigate the associations between blood benzene levels and the prevalence of heart diseases, as well as myocardial injury biomarkers, using data from the National Health and Nutrition Examination Survey (NHANES).
A total of 3 546 participants with available blood benzene measurements and heart disease questionnaire data were included in the study. Weighted logistic regression and weighted generalized linear models were used to perform multivariable-adjusted analyses. Restricted cubic spline (RCS) models were constructed to explore potential nonlinear relationships.
After natural logarithmic transformation, each one-unit increase in blood benzene was significantly associated with a higher odds of congestive heart failure (OR=1.59, 95% CI: 1.03-2.44, P=0.037), coronary heart disease (OR=1.59, 95% CI: 1.08-2.34, P=0.020), and myocardial infarction (OR=1.39, 95% CI:1.07-1.81, P=0.013). Meanwhile, serum lactate dehydrogenase levels increased by an average of 4.78 U/L (95% CI: 2.61-6.96, P<0.001), and high-sensitivity cardiac troponin I levels increased by an average of 1.10 ng/L (95% CI: 0.00-2.20, P=0.050). Although RCS analyses did not reveal significant non-linear associations, they supported a positive dose-response and dose-effect relationship between blood benzene levels and these adverse cardiac outcomes.
Blood benzene levels are significantly positively associated with the odds of heart disease and cardiac injury biomarkers, providing important clues for further investigation into the potential impact of low-level benzene exposure on cardiovascular health.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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