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Outline
To identify key microRNAs involved in idiopathic pulmonary fibrosis (IPF) and investigate the underlying mechanisms.
Analysis of miRNA expression in lung tissues from IPF patients revealed a significant upregulation of miR-205 (logFC=1.91, adj. P. Value<0.05). In vitro experiments confirmed that miR-205 directly targets and suppresses NKD1 expression, thereby modulating the Wnt/β-Catenin signaling pathway and influencing epithelial-mesenchymal transition (EMT), which in turn regulates cell migration and fibrotic progression. Lipid nanoparticles encapsulating a miR-205 inhibitor (i205-LNP) were formulated and evaluated for therapeutic efficacy in a mouse model of pulmonary fibrosis. Following intratracheal administration, i205-LNP significantly upregulated NKD1 expression by approximately 4.05-fold compared to the model group (P<0.05) and reduced the levels of fibrosis-related markers, including α-SMA (approximately 15%, P<0.001), and Col1a1 (approximately 25%, P<0.001) in lung tissues. Consequently, pulmonary inflammation and fibrosis were alleviated, accompanied by attenuated body weight loss and improved survival rates in treated mice.
miR-205 promotes the pathogenesis of idiopathic pulmonary fibrosis by suppressing its target gene NKD1 via the Wnt-EMT signaling pathway.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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