Full
Outline
To explore the impact of early life factors on the initial establishment of infant gut microbiota and their association with allergic diseases in infancy.
A nested case-control study was conducted involving 82 samples from the maternal-infant cohorts established at West China Second University Hospital and Chengdu Women’s and Children’s Central Hospital.
In the vaginal delivery group, the incidence of allergic diseases in infants (30.30%) was lower than that in the cesarean section group (51.02%), with no statistically significant difference; in the breastfeeding group, the incidence (31.81%) was lower than that in the mixed feeding group (55.26%), and the difference was statistically significant (P=0.063; P=0.032). On day 0, the Simpson index in the allergic group was significantly higher than that in the healthy group (P<0.05). By day 30, the healthy group exhibited more favorable microbial richness-related indices of the gut microbiota. On day 7, the relative abundance of Bdellovibrionota in the allergic mixed-fed group was significantly higher than that in other groups (P<0.05). The relative abundance of Bifidobacterium in feces was significantly higher in the healthy group than in the allergic group on day 7 (P<0.05), and the abundance of Bifidobacterium in breast milk of the healthy group remained higher than that of the allergic group from day 0 to day 30.
Vaginal delivery is conducive to maintaining the diversity of gut microbiota in early infancy and establishing a gut microbiota pattern dominated by Bifidobacterium. Meanwhile, breastfeeding promotes the colonization of probiotics such as Bifidobacterium, thereby reducing the long-term risk of allergies in infants.
189
79
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
