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Genome-wide cross-trait association analysis reveals the shared genetic architecture between alcohol consumption and bone mineral density
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Si-rui ZHENG1, Tao HAN1, Ting YU2, Jin-yu ZHOU1, Xia JIANG1, 2, Qin ZHAO3
Modern Preventive Medicine | 2026, 53(14) : 2639 - 2647
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Modern Preventive Medicine | 2026, 53(14): 2639-2647
• Health and Social Behavior •
Genome-wide cross-trait association analysis reveals the shared genetic architecture between alcohol consumption and bone mineral density
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Si-rui ZHENG1, Tao HAN1, Ting YU2, Jin-yu ZHOU1, Xia JIANG1, 2, Qin ZHAO3
Affiliations
  • Department of Nutrition and Food Hygiene, West China School of Public Health/West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Published: 2026-07-25 doi: 10.20043/j.cnki.MPM.202601227
Outline
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Objective

To systematically investigate the genetic association and shared biological mechanisms between weekly alcohol consumption (DrnkWk) and estimated heel bone mineral density (eBMD) in adults.

Methods

Leveraging large-scale genome-wide association study (GWAS) summary statistics from the UK Biobank and the GSCAN consortium, we integrated linkage disequilibrium score regression (LDSC), local genetic correlation analysis (SUPERGNOVA), cross-trait meta-analysis (PLEIO), gene-based association analysis (MAGMA), and bidirectional two-sample Mendelian randomization (MR) to comprehensively assess global and local genetic correlations, pleiotropic loci, and causal relationships between DrnkWk and eBMD.

Results

No significant genome-wide genetic correlation was observed (rg=-0.018, 95%CI: -0.050-0.014, P=0.26); while SUPERGNOVA identified 3 genomic regions with significant local genetic correlations. PLEIO revealed 35 pleiotropic loci (including 9 novel loci), and MAGMA implicated 30 shared genes. Bidirectional MR provided no evidence of a causal effect (forward MR:β=-0.051, P=0.12; reverse MR:β=-0.009, P=0.08).

Conclusion

The epidemiological association between alcohol consumption and bone density is likely driven by shared biological pathways and pleiotropic genetic architecture rather than direct causality, offering new insights for genetic risk stratification and targeted prevention strategies for osteoporosis.

Alcohol consumption  /  Bone mineral density  /  Genome-wide association study  /  Genetic pleiotropy  /  Mendelian randomization
郑思睿, 韩韬, 于婷, 周进宇, 姜侠, 赵琴. 全基因组跨性状关联分析揭示饮酒与骨密度的共享遗传基础. 现代预防医学, 2026 , 53 (14) : 2639 -2647 . DOI: 10.20043/j.cnki.MPM.202601227
Si-rui ZHENG, Tao HAN, Ting YU, Jin-yu ZHOU, Xia JIANG, Qin ZHAO. Genome-wide cross-trait association analysis reveals the shared genetic architecture between alcohol consumption and bone mineral density[J]. Modern Preventive Medicine, 2026 , 53 (14) : 2639 -2647 . DOI: 10.20043/j.cnki.MPM.202601227
Appendix
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Year 2026 volume 53 Issue 14
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Article Info
doi: 10.20043/j.cnki.MPM.202601227
  • Receive Date：2026-01-14
  • Online Date：2026-09-28
  • Published：2026-07-25
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History
  • Received：2026-01-14
Funding
Affiliations
    Department of Nutrition and Food Hygiene, West China School of Public Health/West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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