Full
Outline
To investigate the association between long-term PM10 exposure and dyslipidemia, including its subtypes, and to explore effect heterogeneity across populations.
Data were from the Guizhou Population Health Cohort Study, with baseline in 2010 and follow-up from 2016-2020, including 2 503 adults. Annual PM10 exposure during 2005-2010 was estimated using a high-resolution spatial model. Time-dependent Cox models estimated hazard ratios (HR) and 95% confidence intervals (CI) for dyslipidemia and its subtypes. Subgroup analyses were conducted by age, sex, ethnicity, occupation, smoking, alcohol use, and indoor air conditions.
Over 17 333.5 person-years (median follow-up 6.63 years), 852 dyslipidemia cases occurred (49.15/1 000 person-years). Each 1 SD increase in PM10(5.90 μg/m2) was associated with HR=1.204 (95%CI: 1.106-1.310) for dyslipidemia, remaining robust in dual- and multi-pollutant models. PM10 was mainly associated with elevated LDL-C (HR=1.649, 95%CI: 1.424-1.909). Stronger associations were observed among ethnic minorities, manual laborers, and participants using no clean fuel or lacking ventilation (P for interaction<0.05).
Long-term PM10 exposure increases dyslipidemia risk, especially elevated LDL-C, with stronger effects in ethnic minorities, manual laborers, and those with poor indoor air conditions, emphasizing the need for targeted air pollution control for susceptible populations.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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