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Outline
To explore the association between alcohol consumption and the risk of diabetes mellitus (DM) in adult males.
This study utilized data from the Guizhou Natural Population Cohort Study. The cohort was established between November 2010 and December 2012, and a follow-up survey was conducted on the baseline participants from April 2016 to October 2020. Participants were divided based on their baseline alcohol consumption including daily alcohol consumption, drinking frequency, and type of alcohol consumed. Cox proportional hazards regression model were employed to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (95%CIs) for evaluating the association between alcohol consumption and the risk of DM. Restricted cubic spline analysis was performed to characterize the dose-response relationship between daily alcohol consumption and the incidence of DM. Additionally,subgroup analysis was conducted for different baseline variables.
A total of 3 232 participants were enrolled in this study, and 346 cases of DM were identified during a median follow-up period of 6.64 years. The incidence rate of DM in this study population was 15.03/1 000 person-years. Compared with non-drinking participant, those with moderate alcohol consumption(aHR=1.40, 95%CI=1.04-1.89), heavy alcohol consumption(aHR=1.47, 95%CI=1.09-2.00), drinking 1-7 times per week(aHR=1.33,95%CI=1.01-1.73), drinking >7 times per week(aHR=1.57, 95%CI=1.12-2.19), consuming high degree liquor (aHR=1.58, 95%CI=1.15-2.17) had a higher risk of incident DM. A linear relationship was observed between daily alcohol consumption and the risk of DM, with an increased risk of DM found at all levels of alcohol consumption exceeding 22.13g/d. Subgroup analysis revealed that heavy alcohol consumption, drinking >7 times per week, consumption of high degree liquor in individuals aged <45 years, smoking, BMI ≥24 kg/m2, and low physical activity were significantly associated with the risk of DM.
Alcohol consumption is closely associated with the incidence of DM. Hence, reducing alcohol consumption can be used as a measure for DM prevention.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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