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Outline
To investigate the relationship between body mass index (BMI) and diminished ovarian reserve (DOR) in women from southwestern China, analyzing the correlation between BMI and ovarian reserve markers: anti-Müllerian hormone (AMH) and antral follicle count (AFC).
A 1:1 age-matched case-control study was conducted, enrolling 3 751 women with DOR and 3 751 women with normal ovarian reserve who sought assisted reproductive services at a tertiary hospital in Sichuan Province between January 2022 and August 2024. Conditional logistic regression analysis and restricted cubic spline models were employed to examine the association and dose-response relationship between BMI and DOR. Spearman correlation and multivariable linear regression analyses were applied to assess the relationships between BMI and AMH and AFC.
Conditional logistic regression analysis revealed a significant association between obesity (OR=1.394, 95% CI: 1.112-1.747) and DOR. After adjusting for ethnicity, occupation, marital status, education level, smoking, and alcohol consumption, obesity (OR=1.357, 95% CI: 1.065-1.730) remained a risk factor for DOR. No non-linear relationship was observed between BMI and DOR. Spearman correlation analysis showed that both AMH and AFC were negatively correlated with BMI (P<0.001). In multivariable linear regression analyses adjusting for confounders, BMI demonstrated a negative association with AMH (P<0.001), whereas no significant association was observed between BMI and AFC (P>0.05).
Obesity is a risk factor for diminished ovarian reserve. BMI is negatively associated with AMH but not significantly correlated with AFC.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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