Full
Outline
To identify a novel plasma protein biomarker panel for predicting mild cognitive impairment (MCI) and Alzheimer’s disease (AD) using machine learning algorithms, and to provide evidence for early diagnosis of AD.
A total of 566 eligible participants were enrolled from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, and baseline plasma proteomic data were collected. Random forest, Lasso regression, and support vector machine were applied to screen plasma proteins that effectively discriminate MCI and AD. Correlation analyses with cerebrospinal fluid biomarkers and cognitive scales, and Mendelian randomization analysis were conducted. The model was validated in the GEO and UK Biobank databases.
Ten core plasma biomarkers, including apolipoprotein AII, apolipoprotein E, transthyretin (TTR), were consistently identified by the three algorithms and showed strong correlations with cerebrospinal fluid biomarkers and cognitive scores. Mendelian randomization indicated an inverse association between TTR and AD risk. The area under the curve (AUC) of the tenbiomarker panel was 0.929 for predicting MCI and 0.932 for AD. The panel achieved an AUC of 0.871 in the GEO dataset. When combined with age, sex and APOE ε4 status, the panel yielded an AUC of 0.856 for predicting incident AD over an average of 14 years in the UK Biobank.
The newly identified plasma protein panel can effectively predict the occurrence of MCI and AD, providing a noninvasive tool for early screening and prevention of AD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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