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Outline
To explore the mediating role of frailty between grip strength and cognitive function in community-dwelling older adults and the moderating effect of age.
A convenience sample of 818 community-dwelling older adults was recruited from Qixia District, Nanjing, Jiangsu Province, between July and August 2024. Cognitive function was assessed using the Beijing version of the Montreal Cognitive Assessment (MoCA), frailty status was assessed using the FRAIL Scale (The FRAIL Scale, FRAIL), and grip strength was measured using an electronic handgrip dynamometer. Moderated mediation analysis was conducted using PROCESS 4.1 (Model 4 and Model 59).
Grip strength was negatively correlated with frailty scale scores (r=-0.252, P<0.001) and positively correlated with cognitive function scale scores (r=0.216, P<0.001). Frailty partially mediated the association between grip strength and cognitive function, with a mediation effect of 0.014 (95%CI: 0.006-0.024), accounting for 21.9% of the total effect. In the age-moderated mediation model, the interaction terms for the first path (grip strength×age group→frailty) and the second path (frailty×age group→cognitive function) were both significant (both P<0.05).
Grip strength influences cognitive function indirectly through frailty, and this mediation pathway is moderated by age. Early screening for frailty and age-specific interventions should be emphasized to preserve cognitive function.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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