Full
Outline
To investigate the association between the high-density lipoprotein cholesterol to cystatin C ratio (HDL-C/CysC) and the risk of chronic kidney disease (CKD) in middle-aged and older Chinese populations.
Utilizing demographic statistics, disease history, physical examination, and blood test data from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2020, we excluded individuals with missing key indicators, pre-existing CKD at baseline, or renal dysfunction. Participants were categorized into quartiles based on HDL-C/CysC ratios. A Cox proportional hazards regression model was employed to examine the relationship between HDL-C/CysC ratio levels and CKD risk, with subgroup analyses conducted by age, sex, and body mass index (BMI).
The study included 6 429 subjects with an age distribution of 59.00 (53.00-66.00) and a 9-year follow-up period. During follow-up, 1 007 incident CKD cases were identified, yielding an incidence density of 20.46 per 1 000 person-years. After adjusting for potential confounding factors, using the lowest quartile (Q1) of HDL-C/CysC ratio as reference, the hazard ratios (HRs) and 95% confidence intervals (CIs) for CKD risk in Q2, Q3, and Q4 were 0.81 (0.68-0.97), 0.50 (0.41-0.61), and 0.22 (0.16-0.29), respectively. A significant inverse association was observed between increasing HDL-C/CysC quartiles and CKD risk (P<0.001).
In middle-aged and older Chinese adults, the HDL-C/CysC ratio is independently and significantly associated with CKD risk. A higher HDL-C/CysC ratio may be a protective factor for CKD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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