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Outline
To investigate the association between altitude and the prevalence of hypertension among residents of Tibet, and to analyze potential mediating factors.
Residents aged 18 and above who had lived in Tibet for 6 months or longer were selected through a multi-stage stratified cluster random sampling method to participate in questionnaire surveys, physical measurements, and laboratory tests. Multivariable logistic regression was employed to explore the association between altitude and hypertension. The mediating roles of hemoglobin were further analyzed.
A total of 3 085 participants were included, among whom 1 062(34.42%) were diagnosed with hypertension. After adjusting for covariates, the multivariable logistic regression showed that for every 1 000 m increase in altitude, the risk of hypertension increased by 42% (OR=1.42, 95%CI: 1.16-1.73, P<0.05). Compared with residents living at altitudes below 3 500 m, those at 3 500-<4 000 m and≥4 000 m had ORs of 1.37 and 1.61 for hypertension risk, respectively, with a significant linear trend (P for trend <0.05). Mediation analysis indicated that hemoglobin significantly mediated the association between altitude and hypertension, with mediation effect proportions of 17.80% (95%CI: 3.10%-32.60%, P<0.05).
Altitude is positively associated with the risk of hypertension among residents in Tibet. It is recommended to strengthen the monitoring of blood pressure and hemoglobin levels in populations living at high altitudes, in order to reduce the risk of hypertension.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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