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Association of very-low-density lipoprotein cholesterol with atherosclerotic cardiovascular disease in long term breast cancer survivors
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Yan-chen ZHAO1, Yun-fei LI1, Jia-he WANG1, Xi-zi SUN1, Zhi-yuan WU2, Xiu-hua GUO1, Li-xin TAO1
Modern Preventive Medicine | 2026, 53(8) : 1530 - 1536
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Modern Preventive Medicine | 2026, 53(8): 1530-1536
• Clinical Medicine and Prevention •
Association of very-low-density lipoprotein cholesterol with atherosclerotic cardiovascular disease in long term breast cancer survivors
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Yan-chen ZHAO1, Yun-fei LI1, Jia-he WANG1, Xi-zi SUN1, Zhi-yuan WU2, Xiu-hua GUO1, Li-xin TAO1
Affiliations
  • Beijing Key Laboratory of Environment and Aging, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China
Published: 2026-04-25 doi: 10.20043/j.cnki.MPM.202510098
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Objective

To investigate the association between very-low-density lipoprotein cholesterol (VLDL-C) and its components with atherosclerotic cardiovascular disease (ASCVD) risk in long-term breast cancer survivors.

Methods

This study included 2 333 female participants with a history of breast cancer diagnosed at least 3 years before baseline in the UK Biobank. Cox proportional hazards models were used to assess the associations of VLDL-C and its components, cholesteryl ester (VLDL-CE) and free cholesterol (VLDL-FC), with ASCVD incidence.

Results

During a median follow-up of 13.9 years, 238 participants developed ASCVD. Compared with the lowest quartile, participants in the highest quartile of VLDL-C had a 61% higher risk of ASCVD (HR=1.61, 95%CI: 1.09-2.37). Similar associations were observed for VLDL-CE and VLDL-FC, with a stronger effect for VLDL-FC. Subgroup analyses revealed that the association between VLDL-C and ASCVD was more significant among participants receiving cancer treatment.

Conclusion

Among long-term breast cancer survivors, elevated VLDL-C and its components are positively associated with ASCVD risk, suggesting their potential as biomarkers for cardiovascular risk assessment in this population.

Breast cancer  /  Atherosclerotic cardiovascular disease  /  Very-low-density lipoprotein  /  UK Biobank
赵彦辰, 李芸菲, 王佳鹤, 孙希子, 武志远, 郭秀花, 陶丽新. 长期乳腺癌患病人群极低密度脂蛋白胆固醇与动脉粥样硬化性心血管疾病的关联研究. 现代预防医学, 2026 , 53 (8) : 1530 -1536 . DOI: 10.20043/j.cnki.MPM.202510098
Yan-chen ZHAO, Yun-fei LI, Jia-he WANG, Xi-zi SUN, Zhi-yuan WU, Xiu-hua GUO, Li-xin TAO. Association of very-low-density lipoprotein cholesterol with atherosclerotic cardiovascular disease in long term breast cancer survivors[J]. Modern Preventive Medicine, 2026 , 53 (8) : 1530 -1536 . DOI: 10.20043/j.cnki.MPM.202510098
Appendix
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Year 2026 volume 53 Issue 8
29
15
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Article Info
doi: 10.20043/j.cnki.MPM.202510098
  • Receive Date：2025-10-13
  • Online Date：2026-11-02
  • Published：2026-04-25
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  • Received：2025-10-13
Funding
Affiliations
    Beijing Key Laboratory of Environment and Aging, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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