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Association between the metabolic score for insulin resistance and the risk of gallstone disease
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Xin WANG1, Meng-lin HE1, Jing LUO1, Yi JIANG1, Xuan BAI1, Lin-jun XIE1, Yi-ting XU1, Hong-yu LI1, Guo-heng JIANG1, Wen-qian YU1, Hong YANG1, Cui-hua ZHANG1, Zi-jie CHEN1, Jin ZHOU2, Yan-mei LOU3, Guang-can LI4, Xue-feng SHAN5, Yang YANG6, Fei LI7, Xin WANG1
Modern Preventive Medicine | 2026, 53(9) : 1569 - 1573
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Modern Preventive Medicine | 2026, 53(9): 1569-1573
• Epidemiology and Statistical Methods •
Association between the metabolic score for insulin resistance and the risk of gallstone disease
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Xin WANG1, Meng-lin HE1, Jing LUO1, Yi JIANG1, Xuan BAI1, Lin-jun XIE1, Yi-ting XU1, Hong-yu LI1, Guo-heng JIANG1, Wen-qian YU1, Hong YANG1, Cui-hua ZHANG1, Zi-jie CHEN1, Jin ZHOU2, Yan-mei LOU3, Guang-can LI4, Xue-feng SHAN5, Yang YANG6, Fei LI7, Xin WANG1
Affiliations
  • Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Published: 2026-05-10 doi: 10.20043/j.cnki.MPM.202510088
Outline
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Objective

This study aims to investigate the association between the metabolic score for insulin resistance (METS-IR) and the risk of gallstone disease (GSD).

Methods

Data were collected from participants who underwent health examinations at four hospital health management centers in Chongqing and Beijing between 2015 and 2020. Multivariable logistic regression analysis was employed to examine the correlation between METS-IR and GSD risk across different centers, and a meta-analysis was conducted to pool the results from each hospital.

Results

A total of 543 371 participants were included in this study, with a GSD prevalence of 8.05%. Multivariable logistic regression analysis revealed a positive correlation between METS-IR and GSD risk, with each unit increase in METS-IR associated with a 3.5% increase in GSD prevalence (OR=1.035, 95% CI:1.027-1.042). After converting METS-IR into categorical variables based on quartiles, the results indicated that the prevalence of GSD in the highest quartile group was 2.268 times that of the lowest quartile group (OR=2.268, 95% CI:1.827-2.709). In various subgroups categorized by age, gender, and gallstone subtype, METS-IR remained significantly positively correlated with the risk of GSD.

Conclusion

Insulin resistance significantly increases the risk of GSD. In the future, screening should be implemented for high-risk populations with insulin resistance to enable early detection and reduce the disease burden of gallstone disease.

Gallstone disease  /  METS-IR  /  Insulin resistance  /  Cross-sectional study
王欣, 何梦琳, 罗菁, 江奕, 白轩, 谢林君, 徐逸婷, 李鸿钰, 江果恒, 于文倩, 杨红, 张翠华, 陈梓洁, 周晋, 娄彦梅, 李光灿, 单雪峰, 杨洋, 李飞, 王新. 胰岛素抵抗代谢评分与胆石症患病风险的关联性研究. 现代预防医学, 2026 , 53 (9) : 1569 -1573 . DOI: 10.20043/j.cnki.MPM.202510088
Xin WANG, Meng-lin HE, Jing LUO, Yi JIANG, Xuan BAI, Lin-jun XIE, Yi-ting XU, Hong-yu LI, Guo-heng JIANG, Wen-qian YU, Hong YANG, Cui-hua ZHANG, Zi-jie CHEN, Jin ZHOU, Yan-mei LOU, Guang-can LI, Xue-feng SHAN, Yang YANG, Fei LI, Xin WANG. Association between the metabolic score for insulin resistance and the risk of gallstone disease[J]. Modern Preventive Medicine, 2026 , 53 (9) : 1569 -1573 . DOI: 10.20043/j.cnki.MPM.202510088
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doi: 10.20043/j.cnki.MPM.202510088
  • Receive Date：2025-10-08
  • Online Date：2026-11-02
  • Published：2026-05-10
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  • Received：2025-10-08
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    Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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