Full
Outline
To investigate the association between Cardiovascular Health (CVH) and cognitive function trajectories.
Data were obtained from five waves (2011-2020) of the China Health and Retirement Longitudinal Study (CHARLS), including participants aged ≥45 years. CVH was assessed using six indicators: tobacco exposure, sleep, body mass index (BMI), non-high-density lipoprotein cholesterol (non-HDL-C), blood glucose, and blood pressure. Group-based trajectory modeling was applied to identify trajectories of cognitive function, and multinomial logistic regression was used to evaluate the association between CVH and cognitive function trajectories.
A total of 5 774 participants was included. Four cognitive trajectories were identified: low-declining, medium-declining, medium-stable and high-stable. Compared with the high-stable group, each one-point increase in CVH score was associated with a reduced risk of entering the low-decline, medium-decline, and medium-stable groups by approximately 1.4%, 0.8%, and 0.5%, respectively (all P<0.01). Tobacco exposure, sleep, and blood pressure were consistently associated with cognitive trajectories (P<0.05), while BMI and non-HDL-C showed significance in selected comparisons.
CVH in middle-aged and older adults is positively associated with cognitive function trajectories. Tobacco exposure, sleep, BMI, non-HDL-C, and blood pressure emerge as key influencing factors. Enhancing CVH, especially through midlife strategies focusing on modifiable lifestyle behaviors and metabolic indicators within an integrated “heart-brain prevention” framework, may represent a promising avenue to mitigate or delay cognitive decline.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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