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Outline
This study aims to identify independent risk factors for pulmonary nodules in a manufacturing workers and to develop and validate a risk prediction model based on key variables. The goal was to provide a quantitative tool for the early identification of high-risk individuals within occupational groups.
A cross-sectional analysis was performed involving 581 employees from a manufacturing enterprise. The cohort comprised 397 individuals without pulmonary nodules and 184 with nodules. Univariate analysis and multivariable logistic regression (forward stepwise method) were used to identify independent predictors and construct the prediction model. The performance of individual variables and the combined model was assessed using receiver operating characteristic (ROC) curve analysis.
Multivariable analysis identified female sex(OR=2.100, 95% CI: 1.163-3.791, P=0.014), smoking (OR=5.757, 95% CI: 3.552-9.332, P<0.001), and years of service (OR=1.113 per year, 95% CI: 1.084-1.143, P<0.001) as significant independent risk factors for pulmonary nodules. The combined prediction model yielded an area under the curve (AUC) of 0.801 (95% CI: 0.762-0.840), with a sensitivity of 62.50% and a specificity of 87.15%.
The risk prediction model, incorporating female sex, smoking history, and longer years of service, exhibits robust discriminative capability. It shows promise as a practical tool for the early screening of pulmonary nodules in occupational populations, such as those in manufacturing. Further external validation in broader and more diverse populations is warranted.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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