Full
Outline
This study aims to explore the relationship between serum vitamin B12 levels and the prevalence of chronic liver diseases in the older adults, and then provide clues for the prevention and treatment of chronic liver diseases.
This study was based on the data from the baseline of the West China Health and Aging Cohort Study from May 2022 to November 2023. A total of 4 563 subjects were included in the study. Multivariable logistic regression analysis and restricted cubic spline analysis were employed to explore the association between serum vitamin B12, liver steatosis or liver fibrosis, and chronic liver diseases.
Multivariable Logistic regression analysis showed that compared with the Q1 level of serum vitamin B12, the Q4 level of vitamin B12 would increase the risk of viral hepatitis (OR: 1.96, 95% CI: 1.23-3.19). Compared with the Q1 level, the Q4 level was positively correlated with liver stiffness measurement (LSM) level, and this positive correlation was strengthened with the increase of serum vitamin B12 level (OR: 1.55, 95% CI: 1.20-1.99). No significant correlation between serum vitamin B12 level and controlled attenuation parameter (CAP) value (P>0.05). In addition, linear correlations of serum vitamin B12 levels with both the hepatic steatosis group and the hepatic fibrosis group were found in this study.
This study found that an increase in serum vitamin B12 levels was associated with viral hepatitis in chronic liver diseases, and higher levels of serum vitamin B12 were also observed in patients with liver fibrosis, suggesting a possible complex relationship between vitamin B12 and liver diseases and providing new clues for further exploring the pathogenesis of liver disease.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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