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Outline
To investigate the association between changes in intrinsic capacity (IC) and the risk of cardiovascular disease (CVD) among middle-aged and older adults.
A total of 2 858 participants from the China Health and Retirement Longitudinal Study (CHARLS) 2011—2018 were included. IC impairment groups were constructed based on changes in five IC domains (locomotion, vitality, cognition, psychological, and sensory) between 2011 and 2013. Cox proportional hazards regression was employed to assess the association between IC changes and CVD. Subgroup and sensitivity analyses were also conducted.
During the 7-year follow-up, 526 (18.4%) incident CVD events were recorded. Compared with the intact group, the hazard ratios (HRs) for incident CVD were 1.47 (95% CI: 1.09-1.99) for the improved group, 1.43 (95% CI: 1.09-1.86) for the persistently mildly impaired group, and 1.74 (95% CI: 1.28-2.37) for the persistently severely impaired group. Compared with the persistently impaired group, the risk of CVD was lower in the improved group (HR=0.58, 95% CI: 0.45-0.76). Subgroup analysis showed an interaction between IC changes and age (P for interaction <0.05).
Persistent IC impairment significantly increases the risk of cardiovascular disease, with risk rising progressively according to the severity of impairment, whereas improvements in intrinsic capacity are associated with a reduced risk.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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