Full
Outline
To investigate the association between metabolic syndrome (MetS) and its components with cognitive frailty (CF) in older adults, and to analyze variations in this association across different population subgroups, thereby providing a scientific basis for targeted interventions.
Guided by the health ecology theory, this study utilized data from the China Health and Retirement Longitudinal Study (CHARLS). A total of 2 695 participants aged 60 years or older were included.MetS was diagnosed according to the Chinese Guidelines for Type 2 Diabetes Prevention and Treatment (2020 edition), while CF was assessed using the Frailty Phenotype (FP) combined with the Mini-Mental State Examination (MMSE). Logistic regression models and subgroup analyses were employed to evaluate the association between MetS and CF.
After adjusting for multiple factors, it was found that MetS was associated with CF (OR=1.169, 95% CI: 1.016-1.346). Component analysis showed that central obesity was independently associated with CF (OR=1.233, 95% CI: 1.057-1.416). As the number of MetS components increased, the OR for its association with CF also correspondingly increased. Subgroup analysis found a statistical interaction effect of fall history in the association between MetS and CF (P=0.02). In addition, among individuals who were unmarried, had an education level below primary school, were retired, or had depression, the strength of the association between MetS and CF was numerically higher.
MetS was significantly associated with CF, and this association was modified by factors such as fall history. These findings suggest that targeted interventions addressing MetS and its key components (e.g., central obesity) are crucial for CF prevention.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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