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Outline
To investigate the association between baseline atherogenic index of plasma (AIP) and incident metabolic dysfunction-associated fatty liver disease (MAFLD) risk in non-obese individuals.
This cohort study enrolled 62 868 participants who underwent health examinations in 2006—2007. Participants were stratified into quartiles(Q1-Q4)based on AIP values. Multivariable Cox regression calculated hazard ratios (HRs) and 95%CIs for MAFLD risk across quartiles.
During a mean follow-up of 14.34±5.03 years, there were 25 848 cases of new MAFLD. There were 4 892, 5 758, 6 736 and 8 462 cases in group Q1-Q4, respectively, and the incidence density was 25.23/1 000, 31.15/1 000, 38.77/1 000 and 55.04/1 000 years, respectively. In multivariate Cox regression analysis, compared with Q1, the HR(95%CI)for new-onset MAFLD in Q2-Q4 was 1.16(1.12-1.21), 1.37(1.32-1.43)and 1.80(1.73-1.87) (all P values<0.001).
Elevated baseline AIP is an independent risk factor for incident MAFLD in non-obese individuals.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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