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Outline
Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by its propensity for metastasis and poor prognosis, with pathogenesis closely linked to oxidative stress, metabolic reprogramming, and tumor microenvironment. As a key regulator of antioxidant responses, nuclear factor erythroid 2-related factor 2 (Nrf2) promotes TNBC progression by orchestrating antioxidant defense mechanisms, ferroptosis-protective systems, metabolic reprogramming, and remodeling of the tumor microenvironment. This review summarizes current advances in the mechanisms by which Nrf2 drives TNBC progression, with a particular focus on the molecular pathways through which it regulates oxidative stress,metabolic reprogramming, and the tumor microenvironment to promote tumor progression. Additionally, it evaluates the potential applications of Nrf2 in preventive medicine and public health, providing a theoretical foundation for early intervention and targeted therapy in TNBC.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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