Full
Outline
To evaluate the correlation between the albumin-bilirubin (ALBI) score and non-alcoholic fatty liver disease (NAFLD).
This study was based on data from the National Health and Nutrition Examination Survey (NHANES) 2017—2018 cycle. A total of 5 948 participants who underwent liver transient elastography with complete data were included, comprising 1 995 in the NAFLD group and 3 953 in the non-NAFLD group. Serum albumin and total bilirubin levels were measured using the Roche Cobas 6000 analyzer.
The ALBI score in the NAFLD group was significantly higher than that in the non-NAFLD group (Z=-7.217, P<0.001). After adjusting for covariates including age, sex, race, marital status, education level, poverty income ratio (PIR), body mass index (BMI), smoking, alcohol consumption, hypertension, and diabetes, participants in the highest quartile (Q4) of ALBI score had a significantly increased risk of NAFLD (OR=1.763, 95% CI: 1.476-1.987). Further analysis showed a significant dose-response relationship between ALBI score and NAFLD risk (P<0.001), with no evidence of nonlinearity (P for nonlinearity=0.318). Stratified analysis revealed a significant interaction with age: among participants younger than 60 years, each quartile increase in ALBI score was associated with a 57.6% higher risk of NAFLD (OR=1.576, 95% CI: 1.396-1.848, P<0.05).
The ALBI score is independently and significantly positively associated with the risk of NAFLD, suggesting its potential application in risk assessment of metabolic-related liver disease.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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