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This study aims to explore the association between the Life’s Essential 8(LE8) and the prevalence of Metabolic-associated fatty liver disease(MAFLD) and its different subtypes.
Based on the baseline data of Chinese Cohort of Working Adults(CCWA), study subjects were selected through systematic random sampling. Sociodemographic characteristics and lifestyle behaviors were obtained via questionnaires, and physical examination data were collected. MAFLD was diagnosed based on the physical examination information, and the LE8 score was used to assess LE8. A total of 21 614 participants with complete data were included. A multivariate logistic regression model was employed to analyze the relationship between LE8 scores and the risk of MAFLD.
In the study population, the prevalence of MAFLD was 25.50%. The total population’s LE8 score was 72.81±13.78. Individuals with MAFLD exhibited a significantly lower mean LE8 score (64.59±12.89)compared to those without MAFLD (75.63±12.92). Notably, the lowest LE8 score was observed among patients with diabetic MAFLD (54.60±12.00). Each one-point increment in LE8 was associated with a 7% reduction in the risk of MAFLD occurrence(OR=0.93, 95% CI: 0.92-0.93). Specifically, the risk decreased by 5% for overweight/obese MAFLD (OR=0.95, 95% CI: 0.94-0.95), 2% for metabolic dysfunction/lean MAFLD (OR=0.98, 95% CI: 0.97-0.99), and 10% for diabetic MAFLD (OR=0.90, 95% CI: 0.90-0.91). Furthermore, compared to individuals with a high LE8 score, those with a medium LE8 score had a 4.44-fold increased risk of developing MAFLD (OR=4.44, 95% CI: 4.03-4.89), while those with a low LE8 score had a 13.63-fold increased risk (OR=13.63, 95% CI: 11.67-15.94).
The LE8 score is associated with MAFLD and different subtypes of MAFLD.A lower LE8 score significantly increases the risk of MAFLD and different subtypes of MAFLD. Improving LE8 may serve as an effective strategy for MAFLD prevention.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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