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Outline
The purpose is to analyze the impact of sedentary behavior and depression and their interaction on the risk of all-cause and cardiovascular mortality in the general population.
The study included adults recruited from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2018, with follow-up until December 31, 2019. Cox proportional hazards regression models were used to assess the associations between sedentary behavior, depression, and their interactions with the risks of all-cause and cardiovascular mortality.
A total of 25 836 adults were included, with a median follow-up of 77.0 (44.0-117.0) months. There were 2 312 all-cause deaths, including 688 cardiovascular deaths. After multivariate adjustment, sedentary behavior was associated with increased risks of all-cause mortality (HR=1.3, 95% CI: 1.1-1.4) and cardiovascular mortality (HR=1.4, 95% CI: 1.2-1.7). Depression was also associated with increased risks of all-cause mortality (HR=1.3, 95% CI: 1.1-1.4) and cardiovascular mortality (HR=1.2, 95% CI: 1.0-1.5). Individuals who were both sedentary and depressed had the highest risks of all-cause mortality (HR=1.6, 95% CI: 1.3-1.8) and cardiovascular mortality (HR=1.7, 95% CI: 1.3-2.3). An additive interaction between sedentary behavior and depression was observed for cardiovascular mortality.
Sedentary behavior and depression are independently associated with increased mortality risks, and there is an additive interaction between these factors.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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