Full
Outline
To investigate the association between loneliness and the risk of arthritis incidence among middle-aged and older adults in China.
Based on data from the China Health and Retirement Longitudinal Study（CHARLS）2011—2020, this study included 9 086 middle-aged and older adults who were free of arthritis at baseline. Participants were categorized into loneliness and non-loneliness groups according to Item 9 of the Center for Epidemiologic Studies Depression Scale（CES-D）. The Kaplan-Meier method was used to plot cumulative incidence curves, and Cox proportional hazards regression models were employed to assess the association between loneliness and incident arthritis risk.
By December 1, 2020, the mean follow-up time was 8.1 years, a total of 1 808 incident arthritis cases were recorded during follow-up. The loneliness group exhibited an arthritis incidence density of 29.36 per 1 000 person-years, compared with 23.05 per 1 000 person-years in the non-loneliness group. The cumulative incidence rate of arthritis was significantly higher in the loneliness group compared to the non-loneliness group（χ2=31.849, P<0.001）. After adjusting for multiple confounders, participants in the loneliness group demonstrated a 26% increased risk of arthritis development compared with the non-loneliness group（HR=1.26, 95% CI: 1.14-1.40）. Subgroup analyses stratified by age, sex, residence, educational level, health insurance status, smoking status, alcohol consumption, BMI, physical activity level, and other chronic diseases revealed largely consistent findings.
In the middle-aged and older adult population in China, loneliness is significantly associated with an elevated risk of incident arthritis. Promoting social connectivity and implementing targeted interventions to mitigate loneliness may serve as effective strategies for arthritis prevention in this population.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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