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Outline
To investigate the association between systemic inflammation markers (SII, NHR, MHR, LHR) and metabolic dysfunction-associated steatotic liver disease (MASLD) among employees of coal electricity corporation, providing a basis for early screening of MASLD in occupational populations.
A cross-sectional study was conducted, and 16 912 medical examination employees of a coal electricity corporation in Shanxi Province were included in 2023. Logistic regression was used to analyze correlations, restricted cubic spline (RCS) was performed to explore dose-response relationships, and subgroup analyses was conducted based on demographics, occupation and disease history.
The prevalence of MASLD among coal-electricity workers was 28.03%, and the prevalence was higher in men than in women. Logistic regression analysis found that the highest quartile (Q4) of SII, MHR, and LHR were all significantly associated with the risk of MASLD, with OR (95% CI) of 1.259 (1.066-1.485), 2.166 (1.817-2.582) and 1.272 (1.085-1.491), respectively. The RCS showed that a nonlinear correlation of the four systemic inflammation markers and MASLD (Ptotal <0.05, Pnonlinear <0.05). Subgroup analysis showed that LHR was positively associated with MASLD risk in all subgroups of gender, age groups, metabolic-related diseases and occupational exposure, SII was positively associated in subgroups of males, ≥ 50 years old, no metabolic-related diseases and no occupational exposures, and MHR was also positively associated in subgroups of males, ≥ 40 years old, and no metabolic-related diseases and occupational exposures. NHR was only associated with MASLD in women subgroups.
SII, MHR, NHR and LHR were nonlinearly correlated with the risk of MASLD among coal-electricity workers, and were influenced by gender, age, metabolism-related diseases, and occupational exposures.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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