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Outline
To investigate the relationship between serum perfluorinated and polyfluoroalkyl substances (PFAS) exposure and metabolic abnormalities in overweight and obese children and adolescents.
This study was a cross-sectional design. The study subjects were overweight and obese children and adolescents aged 5-17 years who visited the Department of Child Health Care at the Children’s Hospital Affiliated to Nanjing Medical University from July to October 2022. Logistic regression analysis was used to investigate the association between PFAS exposure and high blood glucose, high triglyceride, high cholesterol, low high-density lipoprotein, hypertension, high uric acid, insulin resistance and ≥2 cardiometabolic abnormalities in overweight and obese children and adolescents. Bayesian kernel machine regression and quantile g-computation were used to analyze the relationship between mixed exposure to PFAS and the risk of metabolic abnormalities in overweight and obese children.
Among the 220 overweight and obese children, 166 were male(75.5%), with an age of 10.7 (8.8, 12.3) years. A total of 131 children (59.1%) had ≥2 cardiometabolic abnormalities. The levels of PFHxA and PFNA were positively correlated with the risk of hypertriglyceridemia in overweight and obese children (ORPFHxA=1.670, 95% CI: 1.005-2.776; ORPFNA=1.415, 95% CI: 1.062-1.883). The concentration of PFHpA was positively correlated with the risk of hypertension (OR=1.980, 95% CI: 1.269-3.087). Four serum PFAS concentrations were positively correlated with the risk of insulin resistance. Serum PFHpA and PFNA concentrations were positively correlated with the risk of ≥2 cardiometabolic abnormalities (ORPFHpA=1.716, 95% CI: 1.155-2.551; ORPFNA=1.324, 95% CI: 1.003-1.749). In overweight and obese children, the mixed exposure to PFAS was positively correlated with the risk of hyperglycemia, insulin resistance, hypertension, hypertriglyceridemia, and ≥2 cardiometabolic abnormalities, with PFHpA having the largest weight.
Exposure to serum PFAS could increase the risk of abnormal glucose and lipid metabolism, hypertension and ≥2 obesity-related metabolic abnormalities in overweight and obese children and adolescents.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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