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The mediating effect of depression in older adults between cardiometabolic multimorbidity and disability status
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Xia HUANG1, 2, 3, Shi-ting ZHANG1, 2, 3, Chun-ying LIU1, 2, 3, Rui-xin KANG1, 2, 3, Hao QIN1, 2, 3
Modern Preventive Medicine | 2025, 52(20) : 3656 - 3661
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Modern Preventive Medicine | 2025, 52(20): 3656-3661
• Epidemiology and Statistical Methods Advances •
The mediating effect of depression in older adults between cardiometabolic multimorbidity and disability status
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Xia HUANG1, 2, 3, Shi-ting ZHANG1, 2, 3, Chun-ying LIU1, 2, 3, Rui-xin KANG1, 2, 3, Hao QIN1, 2, 3
Affiliations
  • School of Public Health, Shandong Second Medical University, Weifang, Shandong 261053, China
Published: 2025-10-25 doi: 10.20043/j.cnki.MPM.202504257
Outline
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Objective

To explore the mediating role of depression between cardiometabolic multimorbidity (CMM) and disability status among older adults, and to provide a theoretical basis for the prevention and management of disability among the elderly.

Methods

Based on cross-sectional data from the China Health and Retirement Longitudinal Study (CHARLS) in 2020, 8 270 elderly individuals aged≥60 years were included. Correlation and mediation analyses were conducted to examine the associations among depression, CMM and disability. The PROCESS 4.1 macro was employed to test the mediating effect of depression, and the mediating variables were verified using the Bootstrap method.

Results

The detection rate of disability was 19.1%. After controlling for confounders, both CMM and depression were positively correlated with disability(r=0.142, r=0.209, P<0.001). CMM significantly predicted disability status of the elderly (β=0.414, t=13.040, P<0.001), with depression accounting for 17.39% of the total effect (β=0.072, 95% CI:0.056-0.091).

Conclusion

Cardiometabolic multimorbidity can directly or indirectly influence the disability status through the mediating role of depression. Relevant authorities should enhance public awareness campaigns and implement integrated intervention strategies addressing both physiological and psychological aspects to mitigate disability risk in older adults.

Older adults  /  Cardiometabolic multimorbidity  /  Depression  /  Disability status  /  Mediating effect
黄霞, 张诗婷, 刘春莹, 康睿欣, 秦浩. 老年人抑郁在心脏代谢性共病和失能状况之间的中介效应. 现代预防医学, 2025 , 52 (20) : 3656 -3661 . DOI: 10.20043/j.cnki.MPM.202504257
Xia HUANG, Shi-ting ZHANG, Chun-ying LIU, Rui-xin KANG, Hao QIN. The mediating effect of depression in older adults between cardiometabolic multimorbidity and disability status[J]. Modern Preventive Medicine, 2025 , 52 (20) : 3656 -3661 . DOI: 10.20043/j.cnki.MPM.202504257
Appendix
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Year 2025 volume 52 Issue 20
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Article Info
doi: 10.20043/j.cnki.MPM.202504257
  • Receive Date：2025-04-13
  • Online Date：2026-10-29
  • Published：2025-10-25
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  • Received：2025-04-13
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    School of Public Health, Shandong Second Medical University, Weifang, Shandong 261053, China
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