Full
Outline
To investigate the association between peripheral blood inflammatory markers and carotid atherosclerotic plaque in an elderly population.
A cross-sectional study was conducted, including 6 569 participants from the West China Elderly Cohort who met inclusion criteria between May 2022 and November 2023. Unconditional Logistic regression was used to examine the relationship between inflammatory markers and carotid atherosclerotic plaque, with stratified and interaction analyses conducted for further insights. Multinomial Logistic regression was applied to explore the associations between inflammatory markers and the severity of carotid atherosclerotic plaques (single/multiple).
Unconditional Logistic regression revealed significant associations between plaque formation risk and white blood cell count (OR=1.06, 95% CI: 1.03-1.10, P<0.001), neutrophils count (OR=1.06, 95% CI: 1.02-1.11, P=0.002), monocytes (OR=2.95, 95% CI: 2.02-4.32, P<0.001), and SIRI (OR=1.13, 95% CI: 1.05-1.22, P<0.001). Stratified analysis identified platelets as significantly associated with plaque formation in elderly individuals with diabetes, with a multiplicative interaction observed (P=0.023).Multinomial Logistic regression revealed that monocytes were specifically associated with the risk of single plaques (OR=2.14,95% CI: 1.33-3.43, P=0.002), whereas white blood cells, neutrophils, monocytes, platelets, neutrophil-lymphocyte ratio (NLR),systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) were linked to the risk of multiple plaques (P<0.05).
Peripheral blood inflammatory markers are closely related to the formation and severity of carotid atherosclerotic plaques in the elderly, providing valuable insights for assessing carotid atherosclerosis risk.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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