Full
Outline
To analyze the drug resistance and genomic characteristics of Salmonella London isolates from Chengdu between 2019 and 2023.
Salmonella isolates from clinical and food sources in Chengdu during 2019-2023 were serologically identified, resulting in 72 Salmonella London strains. Drug susceptibility testing was performed using the microbroth dilution method. Whole-genome sequencing was conducted to analyze the core genome multilocus sequence typing (cgMLST) genetic characteristics and the presence of resistance genes.
The isolates showed the highest resistance to trimethoprim-sulfamethoxazole (76.39%, 55/72), followed by tetracycline (72.22%, 52/72), ampicillin (68.06%, 49/72), and chloramphenicol (62.50%, 45/72). All isolates were sensitive to ertapenem, ceftazidime/avibactam, tigecycline, meropenem, and amikacin. Among the 72 strains, 11 were sensitive to all 17 tested antibiotics. Multidrug resistance was observed in 70.83% (51/72) of the isolates, with the predominant resistance profile being AMP-AMS-CHL-SXT-TET (12.50%, 9/72). Of the 72 strains, 71 were identified as ST155, with 1 untyped. Some strains exhibited allele differences of ≤10, indicating high genetic homology.
The 72 Salmonella London isolates demonstrate high resistance rates and severe multidrug resistance, with the predominant resistance profile being AMP-AMS-CHL-SXT-TET. The high genetic homology among certain strains suggests the potential for foodborne illness outbreaks.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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