Full
Outline
To investigate the relationship between the aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio and the incidence of diabetes in the Chinese population.
Data of Chinese adults from 2010 to 2016 were extracted from the DRYAD database. Cox regression models were employed to explore the association between the AST/ALT ratio and diabetes incidence, while smooth curve fitting was used to identify non-linear relationships. A piecewise linear regression function was applied to determine the optimal risk threshold.
A total of 86 145 participants were included in the study. After adjusting for covariates, a negative correlation was found between the AST/ALT ratio and diabetes incidence (HR=0.44, 95%CI: 0.38-0.51, P<0.001). The piecewise linear regression function identified the optimal risk threshold at 1.3. For values to the left of the threshold, HR=0.3, 95%CI: 0.2-0.3, P<0.001; for values to the right, HR=0.9, 95%CI: 0.7-1.2, P=0.561.
The AST/ALT ratio is a predictor of diabetes occurrence and is negatively correlated with diabetes incidence.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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