Full
Outline
To explore the clinical application value of the blood creatinine to cystatin C ratio (CCR) in diagnosing skeletal muscle mass reduction in patients with non-alcoholic fatty liver disease (NAFLD).
A total of 388 NAFLD patients hospitalized at Karamay Central Hospital from October 2023 to March 2024 were selected and divided into a training set (310 cases) and a validation set (78 cases) at an 8:2 ratio. Clinical data and body composition data were collected for both groups. Multivariate logistic regression analysis was performed to identify risk factors for skeletal muscle mass reduction and to construct a nomogram model. The model’s predictive performance was evaluated using ROC curves and Hosmer-Lem show calibration curves.
Among the 388 patients surveyed, 187 exhibited skeletal muscle mass reduction. Significant differences were observed between the skeletal muscle mass reduction group and the non-reduction group in terms of BMI, CCR, and hs-CRP (P<0.05). Restrictive cubic splines indicated an “L” shaped relationship between CCR and skeletal muscle reduction, while hs-CRP demonstrated a “J” shaped relationship (both P<0.001). Logistic regression analysis revealed that a higher CCR was a protective factor for skeletal muscle mass (OR=8.579, 95%CI:3.459-13.905). The AUC of the ROC curve for the nomogram prediction model was 0.89 (95%CI: 0.856-0.951). The model exhibited good fit, and the calibration plot demonstrated a strong alignment with the standard curve.
BMI, CCR, and hs-CRP are independent risk factors for skeletal muscle mass reduction in NAFLD patients. The established nomogram model can provide individualized risk predictions and assist in the early identification of high-risk populations.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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