Full
Outline
To establish a risk evaluation index system for delayed thrombolysis in patients with acute ischemic stroke (AIS) based on the three-dimensional framework of demand-supply-interaction, and to provide scientific evidence for clinical risk warning and intervention decision-making.
Literature analysis and focus group interviews were used to preliminarily establish an index system. The Delphi method and analytic hierarchy process were employed to determine indicator weights, followed by preliminary validation.
A total of 21 experts were consulted with an average working experience of (22.67±9.46) years, 12 of whom held deputy senior titles or above. The effective questionnaire recovery rate for both rounds was 100%, with an expert authority coefficient of 0.901 and coordination coefficients of 0.238 and 0.290, respectively. The final index system comprised 2 first-level indicators, 10 second-level indicators, and 95 third-level indicators. Classified by the three-dimensional demand-supply-interaction framework, the primary indicators were out-of-hospital delay factors (0.833 3) and in-hospital delay factors (0.166 7). Preliminary validation showed significant positive correlation between the total index score and door-to-needle time (r=0.72, P<0.001).
This study preliminarily constructs an operational risk evaluation index system for delayed thrombolysis in AIS patients, providing a theoretical framework for early risk identification, clinical decision support, and prognosis improvement. However, large-scale prospective studies are needed to further validate its clinical effectiveness.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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