Objective This paper aims to explore how to introduce the concept of risk management into the laboratory quality control and optimize the laboratory quality management strategy. Methods By analyzing the principle of laboratory quality control and the integration mechanism of risk management and quality control, the deficiencies in standardization of quality control procedures, risk prevention mechanism and data utilization feedback in Chinese laboratories are revealed. Results Based on this, optimization paths such as building standardized quality control procedures, multi-dimensional risk prevention system and data-driven monitoring feedback mechanism are proposed. Conclusion The research shows that integrating risk management into laboratory quality control can significantly improve the quality management level, reduce quality risks, and provide a strong quality guarantee for scientific research.

With the continuous improvement of medical informatization level, the application of Hospital Laboratory Information System (LIS) in the medical field is becoming increasingly widespread. As the core link of hospital laboratory information systems, data transmission's security, stability, and efficiency directly affect the quality and efficiency of medical services. This article first outlines the definition and functions of hospital laboratory information systems, as well as the current development status of LIS systems. Subsequently, an in-depth analysis was conducted on the technical requirements for data transmission in hospital laboratory information systems, including the characteristics of data transmission, security requirements, and optimization directions. Through this study, the aim is to provide useful reference and inspiration for the optimization and development of data transmission technology in hospital laboratory information systems.

With the further development of medical education, surgical laboratory equipment plays an important role in teaching and scientific research. The regular maintenance and overhaul of surgical laboratory equipment is of great significance to guarantee the quality of experimental teaching, prolong the service life of the equipment and reduce the maintenance cost. Laboratory management personnel should be fully aware of this, and take appropriate measures to ensure that the equipment is timely and effective maintenance and overhaul. This paper discusses in detail the regular maintenance and overhaul strategy of surgical laboratory equipment in school. Through analyzing the current situation and problems of equipment maintenance, effective maintenance and overhaul measures are proposed in order to improve the use efficiency and service life of equipment, ensure the stable operation of equipment, improve teaching quality, and ensure the safety of students.

Objective To understand the water quality of a remote rural well in a northern city, and to provide rationalized recommendations for the targeted development of a water quality improvement program. Methods The water quality of 32 self-provided wells in the area was sampled during the abundant and dry water periods each year from 2021 to 2023, tested and evaluated in accordance with the Sanitary Standard for Drinking Water (GB/T 5750-2006) and the Hygiene Standards (GB 5749-2006) for testing and evaluation use SPSS 26.0. Results Show that the 192 water samples tested, 144 are qualified, the pass rate is 75.00%. Dry water period pass rate is 84.38%. Abundant water period pass rate is 65.63%. Conclusion The water quality pass rate of a remote rural well in a northern city is lower than the pass rate in the dry season, and the water quality needs to be improved to ensure the safety of drinking water and the health of rural residents.

Objective To study, discuss and analyze the reasons for deviations in drug test results and find out methods for quality control. Methods 150 drug samples from October 2022 to October 2023 were randomly collected and tested using two methods: UV spectrophotometry and high performance liquid chromatography. The results of the drug samples tested by the two methods were comparatively analyzed. Find out the reasons for deviations in drug test results, and finally conduct further research based on the situation of the drugs to find ways to control drug quality. Results The deviation rate of the drug detected by UV spectrophotometry was 4%, and the deviation rate of the test results obtained by high-performance liquid chromatography was 3.33%. The difference between the groups was not statistically significant (P>0.05). The two methods were used to detect the deviation rate. The deviation rate of drug test results is different, but the difference is not significant. Conclusion There are many factors that cause deviations in drug testing results. To ensure that drug testing results have high accuracy, scientific and reasonable testing methods and technologies must be used to ensure the standardization of operations during testing and reduce the impact of variable factors on The influence of test results can reduce errors, improve the accuracy of test results, maximize the efficacy of drugs, and ensure the quality of drugs.

To avoid major differences in the testing process, help customers correctly understand and use reports, and effectively control risks, according to the relevant requirements of Laboratory Accreditation and Inspection Body and Laboratory Mandatory Approval, combined with practical experience, this paper puts forward 10 aspects that should be agreed in the inspection and testing entrustment agreement, analyzes more than 10 items that should be declared in the inspection and testing report, summarizes the key issues that should be paid attention to, and provides general requirements for the industry to refer to, which has a great practical guiding significance for the standardization of inspection and testing activities.

Objective To optimize the detection ability of Staphylococcus aureus in our laboratory by participating in the verification of the detection ability of Staphylococcus aureus in cosmetics organized by the Test and Evaluation Center of Chinese Academy of Inspection and Quarantine. Methods The samples were tested according to the test instructions of ACAS-PT1637 (2023) for the detection ability of Staphylococcus aureus in cosmetics and the Technical Specification for Cosmetic Safety (2015 edition). At the same time, the conventional biochemical detection methods, ATB bacteria identification and fluorescence quantitative PCR amplification were used to detect. Results Staphylococcus aureus was not detected in sample 23-Q777 and Staphylococcus aureus was detected in sample 23-A973. The result of this ability verification is satisfactory. Conclusion By participating in this capability verification, the laboratory not only improved the detection ability of the bacteria, but also effectively demonstrated that the laboratory has the ability to detect Staphylococcus aureus in cosmetics by using a variety of methods.

Objective The microbial contamination status of Sanpao Tai series products circulating in the market from 2019 to 2021 was investigated. Methods According to the national food safety standards (food microbiology inspection), the inspection and detection work was carried out from the total number of Colonies, Coliform, Mold, Staphylococcus aureus and Salmonella, and the relevant enterprise standards were collected and analyzed for the results. Results Within three years, 257 batches of samples from Sanpaotai were sampled, among which the total number of Bacterial colonies, Staphylococcus aureus and Salmonella were all qualified batches, while Boliform bacteria and Mold were unqualified, which needed to be paid attention to. Conclusions Mold and its toxins have great harm to human body. In 2021, mold unqualified rate is determined by enterprise standards, and the unqualified rate is decreased. However, considering that some enterprise standards delete mold items and the original value, the situation of mold pollution is still not optimistic.

Objective To study the detection method of 11a-progesterone and 11a-progesterone acetate by gel permeation chromatography and liquid chromatography, and to provide technical support for market supervision and enterprise quality control. Methods Samples are extracted by ethyl acetate; use 1:1 ethyl acetate: hexane as eluent; purify by gel permeation chromatography (GPC) method; collect the eluent for ${12}\sim {20}\mathrm{\;{min}}$ ; obtain the purified solution from eluent by rotary evaporation; wait for the determination of liquid chromatography. Use 45:55 acetonitrile: water as mobile phase; use C18 $\left({{250}\times {4.6}\mathrm{\;{mm}}}\right)$ chromatographic column for separation; use photo diode array detector for the determination of 11a-progesterone and 11a-progesterone acetate at ${245}\mathrm{\;{nm}}$ . Results The linear correlation coefficient of this method is above 0.995, the recovery rate is ${90.0}\%\sim {102.6}\%$ and 85.1 $\sim {102.7}\%$ , the relative standard deviation (RSD) is ${0.7}\%\sim {2.5}\%$ and ${0.1}\%\sim {8.7}\%$ , the limit of detection is ${0.3}\mathrm{{mg}}/\mathrm{{kg}}$ and 0.6 $\mathrm{{mg}}/\mathrm{{kg}}$ , and the limit of quantification is ${1.0}\mathrm{{mg}}/\mathrm{{kg}}$ and ${2.0}\mathrm{{mg}}/\mathrm{{kg}}$. Conclusion The method is simple, reliable and accurate, and can be used for the determination of 11a-progesterone acetate and 11a-progesterone acetate in cosmetics.

Objective To study the detection method of 11a-progesterone and 11a-progesterone acetate by gel permeation chromatography and liquid chromatography, and to provide technical support for market supervision and enterprise quality control. Methods Samples are extracted by ethyl acetate; use 1:1 ethyl acetate: hexane as eluent; purify by gel permeation chromatography (GPC) method; collect the eluent for ${12}\sim {20}\mathrm{\;{min}}$ ; obtain the purified solution from eluent by rotary evaporation; wait for the determination of liquid chromatography. Use 45:55 acetonitrile: water as mobile phase; use C18 $\left({{250}\times {4.6}\mathrm{\;{mm}}}\right)$ chromatographic column for separation; use photo diode array detector for the determination of 11a-progesterone and 11a-progesterone acetate at ${245}\mathrm{\;{nm}}$ . Results The linear correlation coefficient of this method is above 0.995, the recovery rate is ${90.0}\%\sim {102.6}\%$ and 85.1 $\sim {102.7}\%$ , the relative standard deviation (RSD) is ${0.7}\%\sim {2.5}\%$ and ${0.1}\%\sim {8.7}\%$ , the limit of detection is ${0.3}\mathrm{{mg}}/\mathrm{{kg}}$ and 0.6 $\mathrm{{mg}}/\mathrm{{kg}}$ , and the limit of quantification is ${1.0}\mathrm{{mg}}/\mathrm{{kg}}$ and ${2.0}\mathrm{{mg}}/\mathrm{{kg}}$. Conclusion The method is simple, reliable and accurate, and can be used for the determination of 11a-progesterone acetate and 11a-progesterone acetate in cosmetics.