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Brain−computer interface (BCI) is a frontier technology that enables bidirectional information exchange between neural tissues and external devices. Broadly speaking, the term "neural tissue" includes not only the human brain itself but also artificially constructed neural tissue models, such as in vitro brain organoids. Through precise sensing and dynamic feedback of neural structural and functional states, BCI is becoming an important technological pathway for advancing experimental paradigms in neuroscience and exploring brain−inspired intelligence. However, current in vitro brain organoid culture still relies on manual operations and therefore suffers from limited stability and consistency; meanwhile, mainstream BCI technologies are still largely restricted to single−modality data acquisition and processing, making it difficult to achieve multidimensional analysis of complex neural network activity. To address these issues, this paper proposes a high−throughput multimodal BCI platform integrating four core modules: closed−loop fully automated brain organoid culture, neuroelectrophysiological interaction, in situ gene detection, and optical imaging. We systematically describe the key technologies and system−integration strategies of this platform, analyze the strengths and bottlenecks of each module, propose feasible paths for technical fusion, and further discuss its potential applications in brain−inspired computing, mechanistic studies of brain diseases, drug screening, and precision medicine.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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