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Progress, challenges, and development recommendations in organoid research and industrial transformation
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Huilin SHI, Chenqi JIN, Ping XU, Yue WANG*
Science & Technology Review | 2026, 44(16) : 169 - 176
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Science & Technology Review | 2026, 44(16): 169-176
• Policy Forum •
Progress, challenges, and development recommendations in organoid research and industrial transformation
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Huilin SHI, Chenqi JIN, Ping XU, Yue WANG*
Affiliations
  • Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China
Published: 2026-08-28 doi: 10.3981/j.issn.1000-7857.2025.04.00061
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In recent years, driven by innovation in stem cell theory and technological breakthroughs, relying on the rapid development of engineering technologies such as microfluidics and 3D bioprinting, significant progress has been made in the field of organoid research. The filed of organoid is gradually completing the transformation process from laboratory research to industrialization, penetration into the application markets of biological models, organ transplantation, and biological computing hardware. This paper systematically reviews the global progress in organoid research and development, accurately assessing the current stage of organoid research and industrialization. The study finds that organoid construction has achieved dual breakthroughs in biomimicry and functionality, unlocking new application scenarios, while the industrial system has begun to take shape. On this basis, the study identifies the critical technical bottlenecks and ethical regulatory challenges that urgently need to be addressed in the field of organoid. It further outlines future development directions, including prioritizing new strategies for vascularization and microenvironment simulation, developing novel technologies for in situ monitoring of organoid culture, and formulating supporting ethical regulatory policies and standards. Furthermore, the paper analyzes the current state of organoid development in China from the perspective of three dimensions as the policy support system, the depth of fundamental research, and the competitiveness of industrial chain. Targeted recommendations for high−quality development of organoid in China are then proposed, including: establishing organoid key R&D program, conducting application pilot and demonstrations, improving the standardization system, and designing a tiered governance framework, which aims to provide a reference for leading China toward new heights in the field of organoid.

organoid  /  biological models  /  organ transplantation  /  biological computing
施慧琳, 靳晨琦, 徐萍, 王玥. 类器官研究与产业转化的进展、挑战与发展建议. 科技导报, 2026 , 44 (16) : 169 -176 . DOI: 10.3981/j.issn.1000-7857.2025.04.00061
Huilin SHI, Chenqi JIN, Ping XU, Yue WANG. Progress, challenges, and development recommendations in organoid research and industrial transformation[J]. Science & Technology Review, 2026 , 44 (16) : 169 -176 . DOI: 10.3981/j.issn.1000-7857.2025.04.00061
Year 2026 volume 44 Issue 16
2445
1396
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Article Info
doi: 10.3981/j.issn.1000-7857.2025.04.00061
  • Receive Date:2025-04-14
  • Online Date:2026-07-29
  • Published:2026-08-28
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  • Received:2025-04-14
  • Revised:2026-06-28
  • Accepted:2026-07-06
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    Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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