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As three−dimensional (3D) in vitro models, organoids recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. This review summarizes recent advances in organoid biofabrication technology. It identifies key development trends focusing on cutting−edge directions such as multi−process integration, multimodal detection and analysis, and automated intelligent systems. Furthermore, it discusses the application progress of organoid biofabrication in disease modeling and mechanistic insights, regenerative medicine and tissue repair, personalized therapeutics and drug development, as well as research in space microgravity environments. Addressing the current landscape in China, this review proposes improvement strategies focusing on biomaterial innovation, equipment technology advancement, and clinical translation pathways, with the aim of accelerating the innovation and application of organoid biofabrication technology in China.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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