Oxidative stress is an important mechanism of cell aging and injury, and extensive exercise can cause oxidative stress damage to cells of multiple systems/organs in body. Probiotic supplements have many biological functions, such as antioxidant and immune regulation. This study focuses on high-level athletes, aiming to clarify the protective effect of probiotic supplements on exercise-related oxidative stress damage, by analyzing the impact of probiotic supplements on oxidative stress, inflammation levels, and immune state. Oxidative stress indicators are serum malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH), and total antioxidant capacity (TAOC); Inflammatory markers include serum C-reactive protein (CRP) and tumor necrosis factor-α (TNF)-α, and the level of interleukin-6 (IL-6); Immune indicators include peripheral blood CD4+, CD8+, and CD4+CD25+T cell counts. The results showed that probiotic supplements can increase the levels of SOD, GSH, TAOC, CD4+CD25+T cell counts, and reduce the levels of MDA, TNF-α, CD4+, and CD8+ cell counts, indicating that probiotic supplements can improve the oxidative stress and inflammation caused by extensive exercise, and improve immune regulatory functions.

oxidative stress  /  cell injury  /  probiotic supplements  /  antioxidant capacity  /  inflammatory state  /  immune regulation