With the acceleration of population aging, the incidence of senile depression is increasing year by year, which seriously threatens the physical and mental health of the elder adults. As a special group of patients, the senile depression patients are often accompanied with physical diseases. This study evaluated the antidepressant efficacy and prognostic quality of life (QoL) of cognitive-behavioral therapy (CBT) combined with low-dose Duloxetine in elderly patients of depression with comorbidities. The indicators are the clinical onset time of the antidepressant based on the Hamilton Rating Scale for Depression (HAMD), the antidepressant efficacy based on the Montgomery-Asberg Depression Rating Scale (MADRS), and the Croog QoL. The results show that the clinical effective rate (77.4%) of the treatment group at 2 weeks was significantly higher than that of the control group (60.8%) (P=0.027). The depression level of the treatment group at 1 year was lower than that of the control group (P=0.005), and the QoL of the treatment group at 1 and 1.5 years was significantly higher than that of the control group (P<0.001) (P=0.035). It suggests that the CBT combined with antidepressant can shorten the onset time, improve its efficacy and the overall function and prognostic QoL of the patients, helping them to return to social activities.

senile depression  /  physical diseases  /  cognitive-behavioral therapy  /  prognostic quality of life  /  clinical efficacy times  /  selectiveserotonin-norepinephrine reuptake inhibitor