The progressive intensification of the population aging trend has rendered proactive engagement with this challenge exceedingly imperative. Aging denotes the organ function decline over time, the process of which is closely related to the occurrence of a variety of chronic diseases. To reveal the biological basis of aging and develop effective intervention measures has become an important and urgent issue facing the biomedical community. In this paper, the core issues of aging research were discussed, and the construction of aging model, mechanism exploration, quantification of aging degrees and implementation of intervention strategies were reviewed. The following suggestions are made: a diversified and systematic research system should be adopted in the research of aging; the aging mechanism is interpreted through the thinking combining reductionism and holistic view; a universal, reliable and highly sensitive detection system should be explored, and accurate and efficient aging intervention strategies should be developed to address the challenges posed by population aging.

aging mechanisms  /  intervention strategies  /  population aging  /  biomedical research