Scientific problem identification in real-world research is the cornerstone for conducting in-depth studies that result in high-quality real world evidence.This study, taking the descriptive statistical analysis of real-world actual diagnostic and treatment data of the persistent vegetative state (PVS) at the Vegetative Wake-up Promotion Centre of Xi'an Traditional Chinese Medicine Encephalopathy Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine as an example, comprehensively collected demographic information of PVS patients including Chinese and western medical doctors, their disease conditions, speciality examinations, laboratory examinations, scale examinations, information on Chinese medicine evidence and identification and type indicators and treatment indicators.The results found that the combination of Chinese and Western medicines such as acupuncture and moxibustion became one of the optional and effective treatments for PVS, but there were problems such as unclear treatment effects under complex interventions and inconsistency in the way evidence was classified.The analysis demonstrated the scientific problem discovery process of combining PVS clinical healthcare practice with the TCM clinical real world study.It also lays a foundation for further summarising the efficacy and diagnostic and treatment experience of Chinese medicine in promoting awakening of PVS, predicting the prognosis and likelihood of awakening of PVS patients, and improving the rate of promoting awakening of patients in persistent vegetative state.

real world study  /  scientific problem identification  /  persistent vegetative state  /  combine traditional Chinese and western medicine